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KMID : 1123920190330010017
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Korean Journal of Oriental Physiology and Pathology
2019 Volume.33 No. 1 p.17 ~ p.24
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Inhibitory Effect of Cymbopogon Citratus Ethanol Extracts on Adipogenesis in 3T3-L1 Preadipocytes
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Jo Yong-Seok
Ju Sung-Min
Hwang Keum-Hee
Kim Min-Sook
Kim Kwang-Sang
Jeon Byung-Hoon
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Abstract
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Cymbopogon citratus, commonly know as lemongrass, prossesses strong antioxidant, anti-tumor and anti-inflammatory properties. Howerver, its anti?obesity activity remains to be elucidated. This study investigated the effect of ethanol extract of Cymbopogon citratus on adipogenesis, and its underlying mechanism, in 3T3-L1 preadipocytes. The results demonstrated that ethanol extracts of Cymbopogon citratus effectively suppressed intercellular lipid accumulation at non-toxic concentrations, and was associated with the down-regulation of adipocyte-specific transcription factors, including C/EBPα and PPARγ, and phosphorylation of AMPKα. Furthermore, ethanol extracts of Cymbopogon citratus increased p21 and p21 expression, while the expression of CDK2, cyclin A and cyclin B1 was reduced. As a result, ethanol extracts of Cymbopogon citratus seems to induce G0/G1 cell cycle arrest of 3T3-L1 cells. On the other hand, ERK and Akt signaling pathways were not involved in anti-adipogenesis by ethanol extracts of Cymbopogon citratus. Taken together, theses results suggest that ethanol extracts of Cymbopogon citratus inhibits adipocyte differentiation in 3T3-L1 cells and can be used as a safe and efficient natural substance to manage anti-obesity.
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KEYWORD
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3T3-L1 cells, Adipocyte differentiation, Adipogenesis, Cell cycle arrest, Cymbopogon citratus, Lemongrass, Obesity
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